Abstract Background and Objectives The p16INK4a (p16), cyclin D1, cyclin‐dependent
kinase (CDK) 4 and retinoblastoma (Rb) genes are components of the Rb pathway that …

The retinoblastoma (Rb) pathway controls the G1-S checkpoint of the cell cycle. Inactivating
mutations and deletions of p16 and Rb and up-regulation of cyclin D1 disrupt this pathway …

We performed the immunohistochemical staining for six G1 check point cell cycle proteins to
study their expression patterns and roles in the gastric carcinogenesis. We studied 76 cases …

The p16-pRb pathway represents a vital cell-cycle checkpoint. In the present study we
investigated the alterations of this G1-phase protein pathway using immunohistochemical …

Background: Recent research has revealed a rapid increase in the number of alterations
underlying oncogenesis and the proteins which regulate the cell cycle. p16 is a cell cycle …

A series of 76 cases of gastrointestinal tract endocrine tumors, including 21 poorly
differentiated endocrine carcinomas (PDECs, small cell carcinomas) and 55 well …

BACKGROUND/AIMS: Cyclin D1 expression is one of the important biologic factors and its
close association with p16/INK4 and retinoblastoma protein expression has been proven in …

The cell cycle progression is regulated by interactions of specific cyclin-dependent kinases
at the G1-S and G2-M checkpoints. In addition, the cell cycle dysregulation plays a major …

AIM: To analyze the correlation between the protein expression of p16 and Rb genes in
gastric carcinoma (GC), to investigate the role of p16 gene in invasion and lymph node …

Cyclin dependent kinase inhibitor 2/multiple tumour suppressor gene 1 (CDKN2/MTS1) and
retinoblastoma (Rb) tumour suppressor genes play important roles in the regulation of the …