Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …

Melatonin is a neurohormone produced by the pineal gland that regulates sleep and
circadian functions. Melatonin also regulates inflammatory and immune processes acting as …

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …

Melatonin is mainly produced in the mammalian pineal gland during the dark phase. Its
secretion from the pineal gland has been classically associated with circadian and circanual …

Melatonin (N‐acetyl‐5‐methoxytryptamine) was initially thought to be produced exclusively
in the pineal gland. Subsequently its synthesis was demonstrated in other organs, for …

After the successful discovery of the melatonin molecule by Aaron B Lerner et al at Yale
University in 1958, melatonin and the pineal gland, a tiny endocrine gland situated at the …

Melatonin is an indolamine synthesized and secreted by the pineal gland along with other
extrapineal sources including immune system cells, the brain, skin and the gastrointestinal …

Chronic inflammation contributes to multiple diseases including cardiovascular diseases,
autoimmune disorders, metabolic disorders, and psychiatric conditions. Melatonin, a …

Melatonin is a highly conserved molecule found in prokaryotes and eukaryotes that acts as
the darkness hormone, translating environmental lighting to the whole body, and as a …