Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key
signaling steps of innate immune activation hence represent promising therapeutic targets …

The inflammatory response that marks Alzheimer's disease (neuroinflammation) is
considered a double-edged sword. Microglia have been shown to play a protective role at …

Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum …

A major challenge in the field of neurodegenerative diseases and brain aging is to identify
the body's intrinsic mechanism that could sense the central nervous system (CNS) damage …

The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …

The central role of the resident innate immune cells of the brain (microglia) in
neurodegeneration has become clear over the past few years largely through genome-wide …

Microglial cell function is implicated in the etiology of Alzheimer's disease by human
genetics. In this issue of Immunity, Krasemann et al.(2017) describe a gene expression …

Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in
the central nervous system, is the primary pathological feature of acute and chronic …

Targeting neuroinflammation via CD33 inhibition and/or TREM2 activation may have
important implications for neurodegeneration in Alzheimer's disease and may be an addition …

Accumulating evidence support that chronic innate neuroinflammation mediated by
microglia and astrocytes is a common feature across neurodegenerative disorders …