Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit

SL McGee, M Hargreaves - Nature Reviews Endocrinology, 2020 - nature.com
Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …

[HTML][HTML] Exercise metabolism and the molecular regulation of skeletal muscle adaptation

B Egan, JR Zierath - Cell metabolism, 2013 - cell.com
Preservation of aerobic fitness and skeletal muscle strength through exercise training can
ameliorate metabolic dysfunction and prevent chronic disease. These benefits are mediated …

Exercise and the regulation of endocrine hormones

AC Hackney, AR Lane - Progress in molecular biology and translational …, 2015 - Elsevier
The endocrine system has profound regulatory effects within the human body and thus the
ability to control and maintain appropriate function within many physiological systems (ie …

The interplay between exercise metabolism, epigenetics, and skeletal muscle remodeling

RA Seaborne, AP Sharples - Exercise and Sport Sciences …, 2020 - journals.lww.com
• Exercise changes the abundance of a number of important metabolites and substrates to
keep our muscles contracting.• These metabolites may serve as substrates to enable …

The molecular bases of training adaptation

VG Coffey, JA Hawley - Sports medicine, 2007 - Springer
Skeletal muscle is a malleable tissue capable of altering the type and amount of protein in
response to disruptions to cellular homeostasis. The process of exerciseinduced adaptation …

Invited review: intracellular signaling in contracting skeletal muscle

K Sakamoto, LJ Goodyear - Journal of applied physiology, 2002 - journals.physiology.org
Physical exercise is a significant stimulus for the regulation of multiple metabolic and
transcriptional processes in skeletal muscle. For example, exercise increases skeletal …

Exercise-induced skeletal muscle signaling pathways and human athletic performance

DM Camera, WJ Smiles, JA Hawley - Free Radical Biology and Medicine, 2016 - Elsevier
Skeletal muscle is a highly malleable tissue capable of altering its phenotype in response to
external stimuli including exercise. This response is determined by the mode,(endurance …

Physical exercise and epigenetic modifications in skeletal muscle

M Widmann, AM Nieß, B Munz - Sports medicine, 2019 - Springer
Physical activity and sports play major roles in the overall health status of humans. It is well
known that regular exercise helps to lower the risk for a broad variety of health problems …

Exercise metabolism and adaptation in skeletal muscle

JAB Smith, KA Murach, KA Dyar… - Nature Reviews Molecular …, 2023 - nature.com
Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training

B Egan, AP Sharples - Physiological Reviews, 2023 - journals.physiology.org
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …