Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) pathway mediates multiple cellular functions critical to tumor initiation, progression …

Simple Summary PI3K signaling pathway plays an essential role in many cellular processes
and is frequently altered in breast cancer, leading to increased tumor growth and reduced …

Breast cancer is the cancer with the highest prevalence in women and is the number‐one
cause of cancer mortality worldwide. Cell transduction is a fundamental process in the …

The phosphoinositide 3 kinase (PI3K)/Akt/mammalian (or mechanistic) target of rapamycin
(mTOR) pathway is a complicated intracellular pathway, which leads to cell growth and …

Background: The most recurrent and considered second most frequent cause of cancer-
related deaths worldwide in women is the breast cancer. The key to diagnosis is early …

The PI3K/Akt/mTOR signaling pathway is involved in the inhibition of tumor cell apoptosis,
the promotion of cell survival, cell cycle regulation, tumor angiogenesis, invasion, and …

Breast cancer (BC) is the most common women cancer and second most common cause of
cancer death in women. A woman living in the United States has 12.3% lifetime risk of being …

Recent advances in genetics and genomics have revealed new pathways that are
aberrantly activated in many breast cancers. Chief among these genetic changes are …

Breast cancer is one of the most prevalent and devastating malignant diseases in women
worldwide. Fortunately, while breast cancer incidence is still increasing, its death rate is …

Breast cancer (BC) is the most commonly diagnosed cancer in women. The PI3K/AKT/mTOR
pathway is among the most frequently dysregulated pathways in patients with BC. The …