Identification of novel non-homologous drug targets against Acinetobacter baumannii using subtractive genomics and comparative metabolic pathway analysis

H Kaur, M Kalia, N Taneja - Microbial Pathogenesis, 2021 - Elsevier
Lack of effective antibiotics and the development of multidrug resistance in clinical isolates
of nosocomial pathogen Acinetobacter baumanni has necessitated the identification of novel …

Identification of putative non-host essential genes and novel drug targets against Acinetobacter baumannii by in silico comparative genome analysis

R Uddin, F Masood, SS Azam, A Wadood - Microbial pathogenesis, 2019 - Elsevier
Acinetobacter baumannii, the gram-negative bacteria emerged as an extremely critical
pathogen causing nosocomial and different kinds of infections. A. baumannii exhibit …

[PDF][PDF] In silico identification of novel drug targets in acinetobacter baumannii by subtractive genomic approach

M Goyal, C Citu, N Singh - Asian J. Pharm. Clin. Res, 2018 - researchgate.net
Objective: Multiple drug resistance (MDR) in bacteria, particularly Gram-negative bacilli, has
significantly hindered the treatment of infections caused by these bacteria. This results in the …

Identification of Druggable Targets for Acinetobacter baumannii Via Subtractive Genomics and Plausible Inhibitors for MurA and MurB

N Kaur, M Khokhar, V Jain, PV Bharatam… - Applied biochemistry …, 2013 - Springer
Emergence of the multidrug-resistant pathogens has rendered the current therapies
ineffective thereby, resulting in the need for new drugs and drug targets. The accumulating …

Computer-Based Identification of Potential Druggable Targets in Multidrug-Resistant Acinetobacter baumannii: A Combined In Silico, In Vitro and In Vivo Study

OH Badie, AF Basyony, R Samir - Microorganisms, 2022 - mdpi.com
The remarkable rise in antimicrobial resistance is alarming for Acinetobacter baumannii,
which necessitates effective strategies for the discovery of promising anti-acinetobacter …

Proteomic Analyses of Acinetobacter baumannii Clinical Isolates to Identify Drug Resistant Mechanism

P Wang, RQ Li, L Wang, WT Yang, QH Zou… - Frontiers in cellular and …, 2021 - frontiersin.org
Acinetobacter baumannii is one of the main causes of nosocomial infections. Increasing
numbers of multidrug-resistant Acinetobacter baumannii cases have been reported in recent …

In Silico Identification of Probable Drug and Vaccine Candidates Against Antibiotic-Resistant Acinetobacter baumannii

E Zadeh Hosseingholi, G Zarrini… - Microbial Drug …, 2020 - liebertpub.com
Acinetobacter baumannii is known as a Gram-negative bacterium that has become one of
the most important health problems due to antibiotic resistance. Today, numerous efforts are …

Screening of potential lead molecules against prioritised targets of multi-drug-resistant-Acinetobacter baumannii – insights from molecular docking, molecular dynamic …

S Skariyachan, M Manjunath… - Journal of Biomolecular …, 2019 - Taylor & Francis
Acinetobacter baumannii, an opportunistic pathogen, has become multi-drug resistant
(MDR) to major classes of antibacterial and poses grave threat to public health. The current …

Genome-Wide Identification of Potential Drug Target in Enterobacteriaceae Family: A Homology-Based Method

M Hadizadeh, SN Tabatabaiepour… - Microbial Drug …, 2018 - liebertpub.com
The Enterobacteriaceae is a large family of Gram-negative, facultative anaerobic, non-spore
forming rod-shaped bacteria that includes harmless and pathogenic organisms. The …

Identification of a Family of Glycoside Derivatives Biologically Active against Acinetobacter baumannii and Other MDR Bacteria Using a QSPR Model

FJ Palacios-Can, J Silva-Sánchez, I León-Rivera… - Pharmaceuticals, 2023 - mdpi.com
As the rate of discovery of new antibacterial compounds for multidrug-resistant bacteria is
declining, there is an urge for the search for molecules that could revert this tendency …