Rationale: Cystic fibrosis (CF) airways disease produces a mucoobstructive lung phenotype
characterized by airways mucus plugging, epithelial mucous cell metaplasia/hyperplasia …

—We investigated how cystic fibrosis (CF) alters the relationship between Cl− and mucin
secretion in cultures of non-CF and CF human tracheobronchial gland mucous (HTGM and …

In the cystic fibrosis (CF) patient, lung function decreases throughout life as a result of
continuous cycles of infection, particularly with Pseudomonas aeruginosa and …

The pathogenesis of mucoinfective lung disease in cystic fibrosis (CF) patients likely
involves poor mucus clearance. A recent model of mucus clearance predicts that mucus flow …

Abnormalities in mucus properties and clearance make a major contribution to the pathology
of cystic fibrosis (CF). Our aim was to test the hypothesis that the defects in CF mucus are a …

Rationale: Cystic fibrosis (CF) is believed to be associated with mucus hypersecretion; thus,
the principal airway gel-forming mucins, MUC5AC and MUC5B, are also expected to be …

The dynamics describing the vicious cycle characteristic of cystic fibrosis (CF) lung disease,
initiated by stagnant mucus and perpetuated by infection and inflammation, remain unclear …

Cystic fibrosis (CF), an autosomal genetic disorder caused by the dysfunction of the cystic
fibrosis transmembrane conductance regulator (CFTR) protein, is characterized by mucus …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a
description of CF lung disease pathophysiology unifying superficial epithelial and …