Synthesis, structure-activity relationship and molecular docking studies of 3-O-flavonol glycosides as cholinesterase inhibitors
The prime objective of this research work is to prepare readily soluble synthetic analogues
of naturally occurring 3-O-flavonol glycosides and then investigate the influence of various …
of naturally occurring 3-O-flavonol glycosides and then investigate the influence of various …
Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies
Flavonoids are one of the largest classes of plant secondary metabolites and are known to
possess a number of significant biological activities for human health. In this study, we …
possess a number of significant biological activities for human health. In this study, we …
Flavonols and 4-thioflavonols as potential acetylcholinesterase and butyrylcholinesterase inhibitors: Synthesis, structure-activity relationship and molecular docking …
To explore new scaffolds for the treat of Alzheimer's disease appears to be an inspiring goal.
In this context, a series of varyingly substituted flavonols and 4-thioflavonols have been …
In this context, a series of varyingly substituted flavonols and 4-thioflavonols have been …
Exploring 3-Benzyloxyflavones as new lead cholinesterase inhibitors: synthesis, structure–activity relationship and molecular modelling simulations
In this protocol, a series of 3-benzyloxyflavone derivatives have been designed,
synthesized, characterized and investigated in vitro as cholinesterase inhibitors. The …
synthesized, characterized and investigated in vitro as cholinesterase inhibitors. The …
Selective cholinesterase inhibitors from Buxus sempervirens L. and their molecular docking studies
IE Orhan, M TH Khan, SA Erdem… - … computer-aided drug …, 2011 - ingentaconnect.com
In this work, two alkaloids namely (+)-buxabenzamidienine (1) and (+)-buxamidine (2) were
isolated from Buxus sempervirens, using bioassay-guided fractionation and isolation …
isolated from Buxus sempervirens, using bioassay-guided fractionation and isolation …
Pharmacological Evaluation and Docking Studies of 3‐Thiadiazolyl‐and Thioxo‐1, 2, 4‐triazolylcoumarin Derivatives as Cholinesterase Inhibitors
Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is considered a
promising strategy for the treatment of Alzheimer's disease (AD). This research project aims …
promising strategy for the treatment of Alzheimer's disease (AD). This research project aims …
Synthesis, Docking Study and Biological Activities Evaluation of 1‐Amidoalkyl‐2‐Naphthol Derivatives as Dual Inhibitors of Cholinesterase and α‐Glucosidase
An efficient green synthesis of 1‐amidoalkyl‐2‐naphthol derivatives 4 a‐s has been
developed, employing phenylboronic acid, by a three component one‐pot condensation …
developed, employing phenylboronic acid, by a three component one‐pot condensation …
Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives
Background Many natural products, particularly phenolic compounds, have been reported to
have a strong inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase …
have a strong inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase …
Biological evaluation and molecular docking studies of 4-aminobenzohydrazide derivatives as cholinesterase inhibitors
Nowadays, inhibition of the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)
enzymes have emerged as an encouraging approach in the treatment of dementia and …
enzymes have emerged as an encouraging approach in the treatment of dementia and …
2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: synthesis, biological activity and molecular modeling
A series of 2-phenylbenzofurans compounds was designed, synthesized and evaluated as
cholinesterase inhibitors. The biological assay experiments showed that most of the …
cholinesterase inhibitors. The biological assay experiments showed that most of the …