Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM
N Ripin, J Boudet, MM Duszczyk… - Proceedings of the …, 2019 - National Acad Sciences
Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–
rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3 …
rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3 …
The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets
RM Scheiba, AI de Opakua, A Díaz-Quintana… - RNA biology, 2014 - Taylor & Francis
Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which
bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal …
bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal …
[HTML][HTML] Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences
EJ Fialcowitz-White, BY Brewer, JD Ballin… - Journal of Biological …, 2007 - ASBMB
The RNA-binding factor HuR is a ubiquitously expressed member of the Hu protein family
that binds and stabilizes mRNAs containing AU-rich elements (AREs). Hu proteins share a …
that binds and stabilizes mRNAs containing AU-rich elements (AREs). Hu proteins share a …
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
M Pabis, GM Popowicz, R Stehle… - Nucleic acids …, 2019 - academic.oup.com
HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that
acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA …
acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA …
The x-ray crystal structure of the first RNA recognition motif and site-directed mutagenesis suggest a possible HuR redox sensing mechanism
RM Benoit, NC Meisner, J Kallen, P Graff… - Journal of molecular …, 2010 - Elsevier
Hu-antigen R (HuR) is a ubiquitous RNA-binding protein that comprises three RNA
recognition motifs (RRMs). The first two tandem RRMs are known to bind to AU-rich …
recognition motifs (RRMs). The first two tandem RRMs are known to bind to AU-rich …
The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding
Human RNA-binding protein (HuR), a ubiquitously expressed member of the Hu protein
family, plays an important role in mRNA degradation and has been implicated as a key post …
family, plays an important role in mRNA degradation and has been implicated as a key post …
HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA
S Park, DG Myszka, M Yu, SJ Littler… - Molecular and cellular …, 2000 - Taylor & Francis
Human neuron-specific RNA-binding protein HuD belongs to the family of Hu proteins and
consists of two N-terminal RNA recognition motifs (RRM1 and-2), a hinge region, and a C …
consists of two N-terminal RNA recognition motifs (RRM1 and-2), a hinge region, and a C …
Structural basis for recognition of AU-rich element RNA by the HuD protein
X Wang, TM Tanaka Hall - Nature structural biology, 2001 - nature.com
Hu proteins bind to adenosine-uridine (AU)-rich elements (AREs) in the 3′ untranslated
regions of many short-lived mRNAs, thereby stabilizing them. Here we report the crystal …
regions of many short-lived mRNAs, thereby stabilizing them. Here we report the crystal …
Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization
CYA Chen, N Xu, AB Shyu - Molecular and cellular biology, 2002 - Taylor & Francis
Human RNA-binding protein HuR, a nucleocytoplasmic shuttling protein, is a ubiquitously
expressed member of the family of Hu proteins, which consist of two N-terminal RNA …
expressed member of the family of Hu proteins, which consist of two N-terminal RNA …
Regulation of HuR structure and function by dihydrotanshinone-I
P Lal, L Cerofolini, VG D'Agostino, C Zucal… - Nucleic acids …, 2017 - academic.oup.com
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich
elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post …
elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post …