Pharmacogenetic role of vitamin D-binding protein and vitamin D receptor polymorphisms in the treatment response of dialysis patients with secondary …

R de Alarcon, B Alburquerque-Gonzalez… - Nephrology Dialysis …, 2022 - academic.oup.com
Secondary hyperparathyroidism (SHPT) is common in chronic kidney disease (CKD) and
dialysis patients, and results in renal osteodystrophy, thus causing the decreased synthesis …

[HTML][HTML] The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism

J Ngamkam, S Vadcharavivad, N Areepium… - Scientific Reports, 2021 - nature.com
The objective of this study was to determine the impact of calcium sensing receptor (CASR)
A990G genetic polymorphism on parathyroid hormone (PTH) lowering response to …

Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients

S Jeong, IW Kim, KH Oh, N Han, KW Joo… - Drug Design …, 2016 - Taylor & Francis
Background Secondary hyperparathyroidism (SHPT) is one of the major risk factors of
morbidity and mortality in end-stage renal disease. Cinacalcet effectively controls SHPT …

Influence of Bsml vitamin D receptor gene polymorphism on the response to a single bolus of calcitrol in hemodialysis patients.

MP Marco, I Martinez, A Betriu, L Craver… - Clinical …, 2001 - europepmc.org
Aims BsmI polymorphism of the vitamin D receptor gene has been linked to
hyperparathyroidism severity and calcitriol levels. The aim of this study was to analyze the …

Association of polymorphic alleles of the calcium-sensing receptor gene with parathyroid hormone secretion in hemodialysis patients

S Yano, T Sugimoto, M Kanzawa, T Tsukamoto… - Nephron, 2000 - karger.com
The present study was performed to investigate the association of calcium-sensing receptor
(CaSR) genotypes with parathyroid hormone (PTH) secretion in hemodialysis patients …

Calcium-sensing receptor gene polymorphism Arg990Gly and its possible effect on response to cinacalcet HCl

HM Rothe, WB Shapiro, WY Sun… - Pharmacogenetics and …, 2005 - journals.lww.com
Cinacalcet, a novel calcimimetic compound, is effective in reducing parathyroid hormone
(PTH) levels in approximately 70% of patients with secondary hyperparathyroidism …

CaSR polymorphism Arg990Gly and response to calcimimetic agents in end-stage kidney disease patients with secondary hyperparathyroidism and in cell culture

H Rothe, W Shapiro, WY Sun, A Matalon - 2008 - Future Medicine
Aims: Calcimimetics are effective in reducing parathyroid hormone (PTH) levels in patients
with secondary hyperparathyroidism, but variability in dose response has been noted. We …

Calcium-sensing receptor genotype and response to cinacalcet in patients undergoing hemodialysis

SM Moe, L Wetherill, BS Decker, D Lai… - Clinical Journal of the …, 2017 - journals.lww.com
Results There were modest associations of CASR SNPs with increased baseline serum
parathyroid hormone and bone alkaline phosphatase primarily with the minor allele in the …

Gene polymorphism of the vitamin D receptor, vitamin D-binding protein and calcium-sensing receptor in respect of calcium-phosphate disturbances in chronic …

AE Grzegorzewska, G Ostromecki - Przeglad Lekarski, 2013 - europepmc.org
Dialysed patients suffering from chronic kidney disease (CKD) show varied levels of
concentration of parathyroid hormone (PTH) in the blood. One of the factors in charge of …

Calcium-Sensing Receptor Gene Polymorphism is Associated with the Parathyroid Response to Low Calcium Dialysate in Hemodialysis Patients with Low …

TJ PARK, JW SEO, KM PACK… - Korean Journal of …, 2007 - pesquisa.bvsalud.org
PURPOSE: Low level of parathyroid hormone (PTH) is a risk factor that might cause hip
fracture in dialysis patients. Low calcium dialysate (LCD) has been suggested as an …