In neuropathic pain the repeated minocycline treatment inhibited the mRNA and protein
expression of the microglial markers and metalloproteinase-9 (MMP-9). The minocycline …

Background: Evidence indicates that neuropathic pain pathogenesis is not confined to
changes in the activity of neuronal systems but involves interactions between neurons …

Inflammatory mediators produced in the injured nerve have been proposed as contributing
factors in the development of neuropathic pain. In this regard an important role is assigned …

It has been demonstrated that spinal microglial activation is involved in formalin-induced
pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral …

We have previously demonstrated that activation of p38 mitogen-activated protein kinase
(p38 MAPK) in the spinal microglia mediates morphine antinociceptive tolerance …

There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …

Neuropathic pain is a challenge for physicians and basic science researchers, because it
often does not respond to routine treatment. The administration of morphine has been …

Activation of p38 mitogen‐activated protein kinase (p38) in spinal microglia is implicated in
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …

Substantial evidence indicates involvement of microglia/macrophages in chronic
neuropathic pain. However, the temporal-spatial features of microglial/macrophage …

Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …