[HTML][HTML] Large animal models of vascularized composite allotransplantation: a review of immune strategies to improve allograft outcomes

AJ Matar, RL Crepeau, GS Mundinger… - Frontiers in …, 2021 - frontiersin.org
Over the past twenty years, significant technical strides have been made in the area of
vascularized composite tissue allotransplantation (VCA). As in solid organ transplantation …

[HTML][HTML] Tolerance induction in vascularized composite allotransplantation—a brief review of preclinical models

L Huelsboemer, M Kauke-Navarro… - Transplant …, 2023 - frontierspartnerships.org
Pre-clinical studies are an obligatory tool to develop and translate novel therapeutic
strategies into clinical practice. Acute and chronic rejection mediated by the recipient's …

Vascularized composite tissue allotransplantation–state of the art

JR Diaz‐Siso, EM Bueno, GC Sisk… - Clinical …, 2013 - Wiley Online Library
Vascularized composite tissue allotransplantation is a viable treatment option for injuries
and defects that involve multiple layers of functional tissue. In the past 15 yr, more than 150 …

[HTML][HTML] Large animal models for vascularized composite allotransplantation

JD Woodall, BD Schultz, M Sosin, RN Barth - Current Transplantation …, 2014 - Springer
Large animal models have served as the foundation for clinical trials in all solid organ
transplantation. Likewise, pre-clinical studies in vascularized composite allotransplantation …

[HTML][HTML] Cellular activation pathways and interaction networks in vascularized composite allotransplantation

L Knoedler, S Knoedler, AC Panayi, CAA Lee… - Frontiers in …, 2023 - frontiersin.org
Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive
surgery that has revolutionized the treatment of patients with devastating injuries, including …

Vascularized composite allograft‐specific characteristics of immune responses

F Issa - Transplant International, 2016 - Wiley Online Library
Vascularized composite allograft (VCA) transplantation, or reconstructive transplantation,
has revolutionized the treatment of complex tissue and functional defects. Despite arriving …

Vascularized composite allotransplantation versus solid organ transplantation: innate-adaptive immune interphase

K Kadono, M Gruszynski, K Azari… - Current opinion in …, 2019 - journals.lww.com
Vascularized composite allotransplantation versus solid orga... : Current Opinion in Organ
Transplantation Vascularized composite allotransplantation versus solid organ …

Improving the Safety of Tolerance Induction: Chimerism and Cellular Co‐Treatment Strategies Applied to Vascularized Composite Allografts

WC Huang, JY Lin, CG Wallace… - Journal of …, 2012 - Wiley Online Library
Although vascularized composite allografts (VCAs) have been performed clinically for a
variety of indications, potential complications from long‐term immunosuppression and graft …

Composite tissue allotransplantation: opportunities and challenges

J Iske, Y Nian, R Maenosono, M Maurer… - Cellular & molecular …, 2019 - nature.com
Vascularized composite allotransplants (VCAs) have unique properties because of diverse
tissue components transplanted en mass as a single unit. In addition to surgery, this type of …

Chimerism‐based experimental models for tolerance induction in vascularized composite allografts: Cleveland clinic research experience

M Siemionow, A Klimczak - Journal of Immunology Research, 2013 - Wiley Online Library
The preclinical experimental models of vascularized composite allografts (VCAs) have been
rapidly developed for the assessment of immunomodulatory protocols for clinical …