Association between CASR Polymorphisms, Calcium Intake, and Colorectal Cancer Risk

KZ Kim, A Shin, J Kim, JW Park, SC Park, HS Choi… - PloS one, 2013 - journals.plos.org
Aim The current study aimed to assess the effect of dietary calcium intake and possible
interactions with calcium-sensing receptor (CASR) gene polymorphisms on colorectal …

CASR rs1801725 polymorphism is associated with the risk and prognosis of colorectal cancer: A case‐control study

YE Diao, Q Xu - Journal of Clinical Laboratory Analysis, 2020 - Wiley Online Library
Background The extracellular calcium‐sensing receptor (CASR) controls body calcium
homeostasis. Increased levels of calcium are associated with protecting against colorectal …

Association of genetic variants in the calcium-sensing receptor with risk of colorectal adenoma

U Peters, N Chatterjee, M Yeager, SJ Chanock… - … Biomarkers & Prevention, 2004 - AACR
Objective: Evidence suggests that calcium prevents colorectal cancer, possibly mediated
through the calcium-sensing receptor (CASR). We assessed the associations between …

Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR)

W Yang, L Liu, Y Masugi, ZR Qian, R Nishihara… - Gut, 2018 - gut.bmj.com
Objective Although evidence suggests an inverse association between calcium intake and
the risk of colorectal cancer, the mechanisms remain unclear. The calcium-sensing receptor …

Genetic variation in calcium-sensing receptor and risk for colon cancer

LM Dong, CM Ulrich, L Hsu, DJ Duggan… - … Biomarkers & Prevention, 2008 - AACR
Background: Experimental and epidemiologic studies have suggested that high calcium
intake is associated with decreased colon cancer risk, yet very limited data are available for …

Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients

E Wesselink, W Gauderman, SI Berndt, H Brenner… - BJC reports, 2024 - nature.com
Background Research on calcium intake as well as variants in the calcium sensor receptor
(CaSR) gene and their interaction in relation to CRC survival is still limited. Methods Data …

Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian …

K Bácsi, E Hitre, JP Kósa, H Horváth, Á Lazáry… - BMC cancer, 2008 - Springer
Background Epidemiological studies suggested the chemopreventive role of higher calcium
intake in colorectal carcinogenesis. We examined genetic polymorphisms that might …

[HTML][HTML] The calcium-sensing receptor: A promising target for prevention of colorectal cancer

A Aggarwal, M Prinz-Wohlgenannt… - … et Biophysica Acta (BBA …, 2015 - Elsevier
The inverse correlation between dietary calcium intake and the risk of colorectal cancer
(CRC) is well known, but poorly understood. Expression of the calcium-sensing receptor …

No Evidence of Gene–Calcium Interactions from Genome-Wide Analysis of Colorectal Cancer Risk

M Du, X Zhang, M Hoffmeister, RE Schoen… - … Biomarkers & Prevention, 2014 - AACR
Background: Calcium intake may reduce risk of colorectal cancer, but the mechanisms
remain unclear. Studies of interaction between calcium intake and SNPs in calcium-related …

Parathyroid hormone gene rs6256 and calcium sensing receptor gene rs1801725 variants are not associated with susceptibility to colorectal cancer in Iran

T Mahmoudi, K Karimi, M Arkani… - Asian Pacific Journal …, 2014 - koreascience.kr
Background: Substantial evidence from epidemiological studies has suggested that
increased levels of calcium may play a protective role against colorectal cancer (CRC) …