[HTML][HTML] Mechanisms of lymphatic metastasis
S Karaman, M Detmar - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel
expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby …
expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby …
Pathways targeting tumor lymphangiogenesis
C Wissmann, M Detmar - Clinical Cancer Research, 2006 - AACR
Tumor metastasis to sentinel lymph nodes represents the first step of tumor dissemination in
most human cancers and serves as a major prognostic indicator for disease progression …
most human cancers and serves as a major prognostic indicator for disease progression …
Tumor and lymph node lymphangiogenesis—impact on cancer metastasis
NE Tobler, M Detmar - Journal of leukocyte biology, 2006 - academic.oup.com
The extent of lymph node (LN) metastasis is a major determinant for the staging and the
prognosis of most human malignancies and often guides therapeutic decisions. Although …
prognosis of most human malignancies and often guides therapeutic decisions. Although …
Lymphatic vessels in cancer metastasis: bridging the gaps
Distant organ metastasis is the most important factor in determining patient survival in
cancer. This is thought to occur via the body's own systems for transporting fluid and cells …
cancer. This is thought to occur via the body's own systems for transporting fluid and cells …
[HTML][HTML] Focus on lymphangiogenesis in tumor metastasis
MG Achen, BK McColl, SA Stacker - Cancer cell, 2005 - cell.com
The major cause of cancer mortality is the metastatic spread of tumor cells that can occur via
multiple routes, including the lymphatic vasculature. Recent research has indicated that …
multiple routes, including the lymphatic vasculature. Recent research has indicated that …
Role of lymphangiogenic factors in tumor metastasis
Y He, T Karpanen, K Alitalo - Biochimica Et Biophysica Acta (BBA)-Reviews …, 2004 - Elsevier
Nearly four centuries after the discovery of lymphatic vessels, the molecular mechanisms
underlying their development are beginning to be elucidated. Vascular endothelial growth …
underlying their development are beginning to be elucidated. Vascular endothelial growth …
Interaction of tumor cells and lymphatic vessels in cancer progression
A Alitalo, M Detmar - Oncogene, 2012 - nature.com
Metastatic spread of cancer through the lymphatic system affects hundreds of thousands of
patients yearly. Growth of new lymphatic vessels, lymphangiogenesis, is activated in cancer …
patients yearly. Growth of new lymphatic vessels, lymphangiogenesis, is activated in cancer …
Lymphatic vessel activation in cancer
S Das, M Skobe - Annals of the New York Academy of …, 2008 - Wiley Online Library
Most cancerous lesions metastasize through the lymphatic system and the status of regional
lymph nodes is the most important indicator of a patient's prognosis. The extent of lymph …
lymph nodes is the most important indicator of a patient's prognosis. The extent of lymph …
Tumor lymphatics
J Sleeman, A Schmid, W Thiele - Seminars in cancer biology, 2009 - Elsevier
In this article we survey more than three centuries of observation and research into tumor-
associated lymphatic vessels, and their role in the metastatic spread of cancer. This …
associated lymphatic vessels, and their role in the metastatic spread of cancer. This …
Multiple roles of lymphatic vessels in tumor progression
Q Ma, LC Dieterich, M Detmar - Current opinion in immunology, 2018 - Elsevier
Highlights•Tumor lymphangiogenesis is associated with a poor prognosis in many cancer
types.•Lymphatic vessels provide a dissemination route for tumor cells.•Lymphatic vessels …
types.•Lymphatic vessels provide a dissemination route for tumor cells.•Lymphatic vessels …