Organogenesis requires tightly coordinated and patterned growth of numerous cell types to
form a fully mature and vascularized organ. Endothelial cells (ECs) that line blood vessels …

The formation, growth and maintenance of our organs, such as our kidneys or pancreas,
requires their coordinated growth alongside the intricate vasculature that pervades them …

The development of increasingly biomimetic human tissue analogs has been a long-
standing goal in two important biomedical applications: drug discovery and regenerative …

In recent years, the development of 3D organoids has opened new avenues of investigation
into development, physiology, and regenerative medicine. Organoid formation and the …

Blood vessels form a highly branched, interconnected, and largely stereotyped network of
tubes that sustains every organ and tissue in vertebrates. How vessels come to take on their …

Organoids are three-dimensional structures that self-organize from human pluripotent stem
cells or primary tissue, potentially serving as a traceable and manipulatable platform to …

The formation and remodeling of a functional circulatory system is critical for sustaining
prenatal and postnatal life. During embryogenesis, newly differentiated endothelial cells …

Adult organs are vascularized by specialized blood vessels. In addition to inter-organ
vascular heterogeneity, each organ is arborized by structurally and functionally diversified …

Organoids are self-organizing 3D cell culture models that are valuable for studying the
mechanisms underlying both development and disease in multiple species, particularly, in …

Organoids are biomimetic tissue analogs that are generated via the self‐organization of
stem cells or adult cells relying on developmental biology principles. They present tissue …