Durch umfangreiche klinische und grundlagenwissenschaftliche Untersuchungen konnte
die zentrale Rolle des Tumornekrosefaktors-α für die Pathogenese chronisch entzündlicher …

Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases
(IBD) and have pathophysiological processes such as bowel necrosis and enteric neurons …

The intestinal epithelium represents an exquisite complex combination of specialized
cellular components, structural organization, as well as fine-tuned maintenance and renewal …

Background Tumor necrosis factor alpha (TNFα) is a proinflammatory cytokine and an
important mediator in the pathophysiology of inflammatory bowel disease (IBD). The effects …

Tumor necrosis factor (TNF) is a pleotropic cytokine involved in a wide range of pathological
processes, including inflammatory bowel disease (IBD). In the past, TNF was recognized as …

The intestinal epithelium constitutes an indispensable single-layered barrier to protect the
body from invading pathogens, antigens or toxins. At the same time, beneficial nutrients and …

Since the Food and Drug Administration approved the first biologic agent, infliximab, to treat
Crohn's disease (CD) in 1998, additional biologic strategies targeting tumor necrosis factor …

Background—Tumour necrosis factor (TNF) α and TNF-β are soluble ligands binding to TNF
receptors with similar activities; soluble TNF receptors neutralise TNF activity by acting as …

TNF plays an integral role in inflammatory bowel disease (IBD), as evidenced by the
dramatic therapeutic responses in Crohn's disease (CD) patients induced by chimeric anti …

Tumor necrosis factor (TNF)-α is a potent pro-inflammatory and pathological cytokines in
inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti …