The conventional view is that estrogen confers female cardioprotection. Estrogen synthesis
depends on androgen availability, with aromatase regulating conversion of testosterone to …

Estrogen in females is conventionally considered a cardioprotective influence, but a role for
estrogen in male cardioprotection has yet to be defined. Estrogen biosynthesis from …

The role of sex steroids in cardioprotection is contentious, with large clinical trials
investigating hormone supplementation failing to deliver outcomes expected from …

The incidence of cardiac hypertrophy, an established risk factor for heart failure, is generally
lower in women compared with men, but this advantage is lost after menopause. Although it …

Important sex differences in the onset and characteristics of cardiovascular disease are
evident, yet the mechanistic details remain unresolved. Men are more susceptible to …

Background Estrogen pretreatment has been shown to attenuate the development of heart
hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF) …

The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following
experimental ischemia/reperfusion injury in the mouse heart. We hypothesized that …

The role of testosterone in cardiovascular (CV) homeostasis is in controversy, and the exact
effects of testosterone on the cardiovascular system remain poorly understood. Testosterone …

We tested the hypothesis that chronic testosterone treatment would promote a
cardioprotective phenotype against ischemia/reperfusion (I/R) injury. For this study, 3-month …

Myocardial ischemia is the leading cause of death in both men and women; however, very
little information exists regarding the effect of testosterone on the response of myocardium to …