Quantitation of Pyridyloxobutyl-DNA Adducts in Tissues of Rats Treated Chronically with (R)- or (S)-N′-Nitrosonornicotine (NNN) in a Carcinogenicity Study
L Zhao, S Balbo, M Wang, P Upadhyaya… - Chemical research in …, 2013 - ACS Publications
We quantified DNA adducts resulting from 2′-hydroxylation of enantiomers of the tobacco-
specific nitrosamine N′-nitrosonornicotine (NNN) in tissues of male F-344 rats after 10, 30 …
specific nitrosamine N′-nitrosonornicotine (NNN) in tissues of male F-344 rats after 10, 30 …
Metabolism in the F344 Rat of 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, a Tobacco-specific Carcinogen
SS Hecht, R Young, CB Chen - Cancer research, 1980 - AACR
The metabolism of the tobacco-specific carcinogen, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-
1-butanone (NNK), was studied in the F344 rat, in which it induces tumors of the nasal …
1-butanone (NNK), was studied in the F344 rat, in which it induces tumors of the nasal …
Metabolism and DNA single strand breaks induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its analogues in primary culture of rat hepatocytes
L Liu, MA Alaoui-Jamali, N El Alami, A Castonguay - Cancer research, 1990 - AACR
Previous studies have shown that the tobacco specific nitrosamine, 4-(methylnitrosamino)-1-
(3-pyridyl)-1-butanone (NNK), is hepatocarcinogenic and results in alkylation of hepatic …
(3-pyridyl)-1-butanone (NNK), is hepatocarcinogenic and results in alkylation of hepatic …
Evaluation of 4-(N-methylnitrosamino)-4-(3-pyridyl)butyric acid as a potential monitor of endogenous nitrosation of nicotine and its metabolites
AR Tricker, G Scherer, C Conze, F Adlkofer… - …, 1993 - academic.oup.com
The potential endogenous nitrosation of nicotine and cotinine to yield 4-(N-
methylnitrosamino)-4-(3-pyridyl) butyric acid (Iso-NNAC) has been studied in smokers and …
methylnitrosamino)-4-(3-pyridyl) butyric acid (Iso-NNAC) has been studied in smokers and …
The Pyridyloxobutyl DNA Adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]guanine, Is Detected in Tissues from 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone-treated A/J Mice
NM Thomson, PM Kenney… - Chemical research in …, 2003 - ACS Publications
The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
Kinetics of DNA methylation by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
A Castonguay, R Tharp, SS Hecht - IARC scientific publications, 1984 - europepmc.org
The carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was injected
intravenously (0.41 mmol/kg) into F344 rats. DNA from target organs (lung, liver) and a non …
intravenously (0.41 mmol/kg) into F344 rats. DNA from target organs (lung, liver) and a non …
Investigations of metabolic precursors to hemoglobin and DNA adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
LA Peterson, SG Carmella, SS Hecht - Carcinogenesis, 1990 - academic.oup.com
Levels of DNA and/or hemoglobin pyridyloxobutylation were compared in A/J mice or F344
rats treated with a single dose of [5-3H] 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone ([5 …
rats treated with a single dose of [5-3H] 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone ([5 …
Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and …
MA Morse, SD LaGreca, SG Amin, FL Chung - Cancer research, 1990 - AACR
The effects of indole-3-carbinol (13C) on lung neoplasia induced by the tobacco-specific
nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were assessed in an A/J …
nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were assessed in an A/J …
Analysis and identification of 2′-deoxyadenosine-derived adducts in lung and liver DNA of F-344 rats treated with the tobacco-specific carcinogen 4 …
ES Carlson, P Upadhyaya, PW Villalta… - Chemical research in …, 2018 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are carcinogenic in animal models and …
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are carcinogenic in animal models and …
Evaluation of the transplacental tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice
LM Anderson, SS Hecht, DE Dixon, LF Dove… - Cancer research, 1989 - AACR
The transplacental tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) was assessed in three strains of mice: A/J; C3H/He× …
1-(3-pyridyl)-1-butanone (NNK) was assessed in three strains of mice: A/J; C3H/He× …