[HTML][HTML] Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein …

M Maesako, K Uemura, M Kubota, A Kuzuya… - Journal of Biological …, 2012 - ASBMB
Accumulating evidence suggests that some dietary patterns, specifically high fat diet (HFD),
increase the risk of developing sporadic Alzheimer disease (AD). Thus, interventions …

[HTML][HTML] Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice

M Maesako, K Uemura, A Iwata, M Kubota… - PloS one, 2013 - journals.plos.org
High fat diet (HFD) is prevalent in many modern societies and HFD-induced metabolic
condition is a growing concern worldwide. It has been previously reported that HFD clearly …

Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice

M Maesako, K Uemura, M Kubota, A Kuzuya… - Neurobiology of …, 2012 - Elsevier
The pathogenesis of Alzheimer's disease (AD) is tightly associated with metabolic
dysfunctions. In particular, a potential link between type 2 diabetes (T2DM) and AD has …

Effect of high-fat diet on cognitive impairment in triple-transgenic mice model of Alzheimer's disease

SK Sah, C Lee, JH Jang, GH Park - Biochemical and biophysical research …, 2017 - Elsevier
Abstract High-fat diet (HFD)-induced obesity is a risk factor for cognitive impairment in
Alzheimer's disease (AD). It has been reported that two typical neuropathological markers of …

[HTML][HTML] The effect of dietary fat consumption on Alzheimer's disease pathogenesis in mouse models

A Amelianchik, L Sweetland-Martin… - Translational Psychiatry, 2022 - nature.com
Alzheimer's disease (AD) is a fatal cognitive disorder with proteinaceous brain deposits,
neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss over time. AD …

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

VKM Halagappa, Z Guo, M Pearson, Y Matsuoka… - Neurobiology of …, 2007 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
decline in cognitive function associated with the neuropathological hallmarks amyloid β …

Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms

S Sarroca, A Gatius, E Rodríguez-Farré… - The Journal of nutritional …, 2021 - Elsevier
Cumulative evidence indicates that excessive consumption of calories from saturated fat
contributes to the development of Alzheimer's disease (AD). Here, we assess the triggering …

Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse …

JM Walker, S Dixit, AC Saulsberry, JM May… - Neurobiology of …, 2017 - Elsevier
This study assessed the extent to which high fat diet (HFD)-induced β-amyloid accumulation
and cognitive decline in APP/PSEN1 mice are reversible through control of fat intake. Ten …

[HTML][HTML] Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and …

PVM Adami, P Galeano, ML Wallinger… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Diet is a modifiable risk factor for Alzheimer's disease (AD), but the mechanisms linking
alterations in peripheral metabolism and cognition remain unclear. Since it is especially …

Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

NV Patel, MN Gordon, KE Connor, RA Good… - Neurobiology of …, 2005 - Elsevier
Dietary influences on Alzheimer disease (AD) are gaining recognition. Because many aging
processes are attenuated in laboratory mammals by caloric restriction (CR), we examined …