Conventional treatment approaches have had little impact on the course of pancreatic
cancer, which has the highest fatality rate among cancers. Gemcitabine, the primary …

The prognosis for patients diagnosed with pancreatic cancer remains dismal, with less than
3% survival at 5 years. Recent studies have demonstrated that high-dose, intravenous …

Background Treatment for pancreatic cancer with pharmacological ascorbate (ascorbic acid,
vitamin C) decreases tumor progression in preclinical models. A phase I clinical trial was …

Purpose: Pharmacologic concentrations of ascorbate may be effective in cancer
therapeutics. We hypothesized that ascorbate concentrations achievable with iv dosing …

Chemoradiation therapy is the mainstay for treatment of locally advanced, borderline
resectable pancreatic cancer. Pharmacologic ascorbate (P-AscH−, ie, intravenous infusions …

The toxicity of pharmacologic ascorbate is mediated by the generation of H2O2 via the
oxidation of ascorbate. Because pancreatic cancer cells are sensitive to H2O2 generated by …

Ascorbic acid is an essential nutrient commonly regarded as an antioxidant. In this study, we
showed that ascorbate at pharmacologic concentrations was a prooxidant, generating …

Pancreatic cancer is among the most lethal cancers with poorly tolerated treatments. There
is increasing interest in using high-dose intravenous ascorbate (IVC) in treating this disease …

Purpose While the benefits of ascorbic acid (vitamin C, ascorbate) as an essential nutrient
are well established, its effects on tumor cells and in tumor treatment are controversial. In …

Abstract Vitamin C (Vit C or Ascorbate) is essential for many fundamental biochemical
processes. Vit C is an essential nutrient with redox functions at normal physiologic …