Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal …
T Aparicio, L Kotelevets, A Tsocas, JP Laigneau… - Gut, 2005 - gut.bmj.com
Background and aims: Leptin, the product of the ob gene, has been suggested to increase
the risk of colon cancer. However, we have shown that although leptin stimulates epithelial …
the risk of colon cancer. However, we have shown that although leptin stimulates epithelial …
Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis
H Endo, K Hosono, T Uchiyama, E Sakai, M Sugiyama… - Gut, 2011 - gut.bmj.com
Background and aims Obesity increases the risk of colorectal cancer (CRC). Serum leptin
levels are markedly elevated in obese individuals, but the involvement of leptin in CRC …
levels are markedly elevated in obese individuals, but the involvement of leptin in CRC …
Leptin is a growth factor for colonic epithelial cells
JCH Hardwick, GR Van Den Brink, GJ Offerhaus… - Gastroenterology, 2001 - Elsevier
Background & Aims: Obesity increases the risk of colon cancer, whereas physical activity
reduces the risk. Plasma levels of leptin increase in proportion to the level of obesity and are …
reduces the risk. Plasma levels of leptin increase in proportion to the level of obesity and are …
Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosa
T Aparicio, S Guilmeau, H Goiot, A Tsocas… - Gastroenterology, 2004 - Elsevier
Background & Aims: Recent studies suggest that leptin, a hormone involved in food intake
regulation, released into the circulation and gastrointestinal juice, may be a growth factor for …
regulation, released into the circulation and gastrointestinal juice, may be a growth factor for …
Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression
T Uchiyama, H Takahashi, H Endo… - International …, 2011 - spandidos-publications.com
Although a number of recent studies have reported the involvement of leptin in colorectal
carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously …
carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously …
Differential effects of leptin on cancer in vitro
P Somasundar, KY Alice, L Vona-Davis… - Journal of Surgical …, 2003 - Elsevier
INTRODUCTION: Leptin, a protein produced by adipocytes, is an important signaling
molecule in energy regulation and food intake. Many obese patients have leptin resistance …
molecule in energy regulation and food intake. Many obese patients have leptin resistance …
Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells
MR Hoda, SJ Keely, LS Bertelsen… - Journal of British …, 2007 - academic.oup.com
Background Obesity is associated with increased levels of leptin. The mitogenic actions of
leptin have been identified in various cell types. Because obesity may be a risk factor for …
leptin have been identified in various cell types. Because obesity may be a risk factor for …
Increased soluble leptin receptor levels are associated with advanced tumor stage in colorectal cancer patients
Background: The leptin receptor is involved in modulating leptin activity, acting as a carrier
protein. A link between leptin or leptin receptor and cancer development has been proposed …
protein. A link between leptin or leptin receptor and cancer development has been proposed …
Overexpression of the obesity hormone leptin in human colorectal cancer
M Koda, M Sulkowska, L Kanczuga-Koda… - Journal of clinical …, 2007 - jcp.bmj.com
Background: Leptin is an adipocyte-derived neurohormone, high levels of which are found
in obese individuals. Leptin controls energy expenditure, acting in the brain, and regulates …
in obese individuals. Leptin controls energy expenditure, acting in the brain, and regulates …
Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3‐kinase‐, rho‐, and rac‐dependent signaling pathways
S Attoub, V Noe, L Pirola, E Bruyneel… - The FASEB …, 2000 - Wiley Online Library
Leptin plays a key role regulating food intake, body weight and fat mass. These critical
parameters are associated with an increased risk for digestive and mammary gland cancer …
parameters are associated with an increased risk for digestive and mammary gland cancer …