Epidermal growth factor (EGF) activates the EGF receptor (EGFR) and stimulates its
internalization and trafficking to lysosomes for degradation. However, a percentage of EGFR …

Receptor tyrosine kinases (RTKs) are critical for normal cell growth, differentiation, and
development, but they contribute to various pathological conditions when disrupted …

Glioblastomas, the most aggressive form of primary brain tumors with a tendency to invade
surrounding healthy brain tissues, remains an incurable disease. Intersectin (ITSN) is a …

Ubiquitylation of receptor tyrosine kinases plays a critical role in regulating the trafficking
and lysosomal degradation of these important signaling molecules. We identified the …

Intersectins (ITSNs) represent a family of multi-domain adaptor proteins that regulate
endocytosis and cell signaling. ITSN genes are highly conserved and present in all …

We previously identified intersectin, a multiple EH and SH3 domain-containing protein, as a
component of the endocytic machinery. Overexpression of the SH3 domains of intersectin …

Intersectin (ITSN) is a molecular scaffold involved in regulating endocytosis and mitogenic
signaling. We previously demonstrated that ITSN transformed rodent fibroblasts, accelerated …

Activated epidermal growth factor receptor (EGFR) continues to signal in the early
endosome, but how this signaling process is regulated is less well understood. Here we …

Malignant gliomas have a tendency to invade diffusely into surrounding healthy brain
tissues, thereby precluding their successful surgical removal. Intersectin1 (ITSN1) as a …

The epidermal growth factor receptor (EGFR) is over‐expressed in a variety of human
cancers. Downstream signalling of this receptor is tightly regulated both spatially and …