The effectiveness of cyanate as an in vitro inhibitor of sickling'and the preliminary evidence
of its clinical usefulness when administered via an extracorporeal route” have stimulated the …

A number of agents that prevent sickling in vitro have been discovered during the past
decade. In general, such agents act directly on the hemoglobin S tetramer to inhibit gelation …

Two compounds that inhibit the sickling of erythrocytes in vitro are sodium cyanate and
glyceraldehyde. The former compound reacts selectivity with the NH2-terminus of the a …

Sickle cell anemia is a genetic disease in which the erythrocytes have lost their diskoid
shape (1) and their pliability because of the intracellular aggregates of hemoglobin S that …

TWO abnormal high oxygen affinity haemoglobins have been studied for their ability to
inhibit the polymerization of deoxy‐Hb S. They were used as models to predict the effect of …

Although pyridoxal phosphate is known to inhibit gelation of purified hemoglobin S,
antisickling activity has never been demonstrated for intact erythrocytes. We incubated …

In this paper we describe a class of affinity reagents that react specifically with hemoglobin S
at the 2, 3-diphosphoglycerate binding site and effectively disrupt the sickling process. The …

As part of our continuing search for new agents which might be useful for the treatment of
sickle‐cell anemia, we have synthesized two cyclic tetrapeptide homologs, cyclo (‐Val‐Glu …

Cyanate and 2, 3-diphosphoglycerate (2, 3-DPG) both influence the oxygen affinity of
hemoglobin. The studies presented here concern the effects of these compounds on the …

Homoserine, asparagine and glutamine do not restore the de-formability of deoxygenated
sickle cells in spite of noticeable morphological changes. These amino acids also do not …