The complex regulation of eNOS (endothelial nitric oxide synthase) in cardiovascular
physiology occurs at multiple stages. eNOS mRNA levels are controlled both at the …

Nitric oxide plays an important role in cardiovascular homeostasis. In this review, the
regulation of the three nitric oxide synthase isoforms in the cardiovascular system are …

Nitric oxide produced by three different isoforms of nitric oxide synthase (NOS) widely
expressed in virtually all vascular cell types is mostly produced by the endothelial isoform …

2498 MARON BA et al. tion of eNOS is dynamically regulated9 and the enzyme is thus
exposed to different concentrations of ROS depending upon where in the cell the protein is …

Reactive oxygen species can function as intracellular messengers, but linking these
signaling events with specific enzymes has been difficult. Purified endothelial nitric-oxide …

The Global Burden of Disease Study identified cardiovascular risk factors as leading causes
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …

Nitric oxide (NO) is an important bio-regulatory molecule in the nervous, immune and
cardiovascular systems. NO is synthesized from one of the guanidino nitrogens of L-arginine …

Endothelial nitric oxide synthase (eNOS) is the primary physiological source of nitric oxide
(NO) that regulates cardiovascular homeostasis. Historically eNOS has been thought to be a …

Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation
of vascular tone is one of the most important. Under physiological conditions vascular NO is …

The family of nitric oxide synthases (NOS) has significant importance in various
physiological mechanisms and is also involved in many pathological processes. Three NOS …