Nitric oxide (NO) is a relative newcomer to pharmacology, as the paper which initiated the
field was published only 25 years ago. Nevertheless its impact is such that to date more than …

In contrast with the short research history of the enzymatic synthesis of nitric oxide (NO), the
introduction of nitrate‐containing compounds for medicinal purposes marked its 150th …

Over the last two decades, it has become evident that decreased bioavailability of
endothelial nitric oxide (NO) produced from endothelial NO synthase (eNOS), referred to as …

Objective—Mice genetically deficient in endothelial nitric oxide synthase (eNOS−/−) are
hypertensive with lower circulating nitrite levels, indicating the importance of constitutively …

The objective of this study was to investigate the regulation of endothelial nitric oxide (NO)
synthase by NO. Partially purified endothelial NO synthase was exposed to authentic NO (10 …

There is a complex pathophysiologic scenario involving nitric oxide (NO), endothelial nitric
oxide synthase (eNOS), and the development of atherosclerosis and unstable atheroma …

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

The role nitric oxide (NO) plays in the cardiovascular system is complex and diverse. Even
more controversial is the role that the inducible NO synthase enzyme (iNOS) serves in …

Endothelial production of nitric oxide is critical to the regulation of vascular responses,
including vascular tone and regional blood flow, leukocyte–endothelial interactions, platelet …

Nitric oxide synthases (NOS) are the major sources of nitric oxide (NO), a small bioactive
molecule involved in the regulation of many cellular processes. One of the most prominent …