Lysis of tumor cells by CD3+ 4-8-16+ T cell receptor alpha beta-clones, regulated via CD3 and CD16 activation sites, recombinant interleukin 2, and interferon beta 1.
RJ Van de Griend, WJ Tax… - … (Baltimore, Md.: 1950 …, 1987 - journals.aai.org
Abstract A small subpopulation (about 2%) of normal CD3+ human T lymphocytes lacks both
CD4 and CD8 antigens. We have cloned these cells from peripheral blood lymphocytes …
CD4 and CD8 antigens. We have cloned these cells from peripheral blood lymphocytes …
Mechanism of cell-mediated cytotoxicity at the single cell level: I. Estimation of cytotoxic T lymphocyte frequency and relative lytic efficiency
E Grimm, B Bonavida - The Journal of Immunology, 1979 - journals.aai.org
A single cell method has been developed for directly measuring the frequency of cytotoxic T
lymphocytes (CTL). The method is based on the ability of CTL to bind corresponding target …
lymphocytes (CTL). The method is based on the ability of CTL to bind corresponding target …
A previously unrecognized large fraction of cytotoxic lymphocyte precursors is present in CD4+ human peripheral blood T cells
D Kabelitz, C Brucker, H Wagner, B Fleischer - Cellular immunology, 1989 - Elsevier
We describe a limiting dilution (LD) culture system in which cell sorter-purified CD4+(and
CD8+) peripheral blood T cells are cocultured with irradiated, anti-CD3 mab-producing …
CD8+) peripheral blood T cells are cocultured with irradiated, anti-CD3 mab-producing …
In Vitro Target Cell Lysis Mediated by Normal Human Lymphocytes (K Cells) or Monocytes: Induction with Guinea Pig IgG1 or IgG2 Antibodies
Å Larsson, C Öhlander - Scandinavian Journal of Immunology, 1975 - Wiley Online Library
Guinea pig IgG1 or IgG2 anti‐dinitrophenyl (DNP) antibody preparations were used for
induction of target cell lysis by normal human lymphocytes (K cells) or monocytes. Target …
induction of target cell lysis by normal human lymphocytes (K cells) or monocytes. Target …
In vivo development of cytolytic T lymphocytes (CTL) to hapten-altered self: MIs-disparate cells facilitate the response by neutralizing IL 2 inhibitor.
SC Gautam, ML Hilfiker, JR Battisto - Journal of immunology …, 1983 - journals.aai.org
Inability to develop CTL in vivo to hapten-altered self can be attributed in part to an inhibitor
of interleukin 2 (IL 2) that is present in the serum of normal mice. We have shown earlier that …
of interleukin 2 (IL 2) that is present in the serum of normal mice. We have shown earlier that …
Cell-mediated lysis of tumor targets directed by murine monoclonal antibodies of IgM and all IgG isotypes.
P Ralph, I Nakoinz - Journal of immunology (Baltimore, Md.: 1950), 1983 - journals.aai.org
Seven murine monoclonal antibodies to antigens expressed on T lymphoma targets were
tested for directing antibody-dependent cellular cytotoxicity (ADCC). Peptone-induced …
tested for directing antibody-dependent cellular cytotoxicity (ADCC). Peptone-induced …
CELLS MEDIATING SPECIFIC IN VITRO CYTOTOXICITY: II. PROBABLE AUTONOMY OF THYMUS-PROCESSED LYMPHOCYTES (TCELLS) FOR THE KILLING OF ALLOGENEIC T …
P Golstein, H Wigzell, H Blomgren… - The Journal of …, 1972 - rupress.org
In order to investigate whether only T cells are involved in a cell-mediated cytotoxic system
in vitro, we tested the cytotoxicity of immune killing cell populations as deprived as possible …
in vitro, we tested the cytotoxicity of immune killing cell populations as deprived as possible …
Antibody-dependent cell-mediated cytotoxicity due to a “null” lymphoid cell
AH Greenberg, L Hudson, L Shen, IM Roitt - Nature New Biology, 1973 - nature.com
ANTIBODY-COATED target cells may be killed by suspensions of lymphoid cells after
depletion of active phagocytes1–4. Harding et al. 5 and Van Boxel et al. 6 also report that a …
depletion of active phagocytes1–4. Harding et al. 5 and Van Boxel et al. 6 also report that a …
Phenotypic and functional characterization of allospecific and nonspecific (NK-and K-like) cytotoxic T lymphocytes generated in human mixed-lymphocyte cultures …
D Santoli, MK Francis, M Trucco - Cellular Immunology, 1981 - Elsevier
Highly efficient cytotoxic cells able to lyse unsensitized, antibody-coated, and relevant
targets were generated de novo following sensitization in allogeneic human mixed …
targets were generated de novo following sensitization in allogeneic human mixed …
ADCC against human erythrocyte target cells: role of the anti-target cell antibodies in determining lymphocyte killer activity.
DL Nelson, DG Poplack, BJ Holiman… - Clinical and …, 1979 - ncbi.nlm.nih.gov
Studies were undertaken to investigate the role of anti-target cell antibodies in determining
whether lymphocytes can mediate antibody-dependent cellular cytotoxicity (ADCC) in vitro …
whether lymphocytes can mediate antibody-dependent cellular cytotoxicity (ADCC) in vitro …