Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers
Polygenic risk scores (PRSs) have shown promise in predicting susceptibility to common
diseases,–. We estimated their added value in clinical risk prediction of five common …
diseases,–. We estimated their added value in clinical risk prediction of five common …
Next generation disparities in human genomics: concerns and remedies
AC Need, DB Goldstein - Trends in Genetics, 2009 - cell.com
Studies of human genetics, particularly genome-wide association studies (GWAS), have
concentrated heavily on European populations, with individuals of African ancestry rarely …
concentrated heavily on European populations, with individuals of African ancestry rarely …
Heterogeneity in polygenic scores for common human traits
This study investigates the creation of polygenic scores (PGS) s for human population
research. PGSs are a linear, usually weighted, combination of risk alleles that estimate the …
research. PGSs are a linear, usually weighted, combination of risk alleles that estimate the …
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
T Ge, MR Irvin, A Patki, V Srinivasasainagendra… - Genome Medicine, 2022 - Springer
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic
and environmental risk factors that disproportionately afflicts communities of color …
and environmental risk factors that disproportionately afflicts communities of color …