Hypochlorous acid, one of the most powerful biological oxidants, is believed to be important
in the pathogenesis of some diseases. The purpose of this study was to further characterise …

The hyperproduction of hypochlorous acid (HOCl), an extremely toxic biological oxidant
generated by neutrophils and monocytes, is involved in the pathogenesis of many diseases …

This study was carried out to investigate HOCl-induced lysis of human erythrocytes. Using
reagent HOCl with isolated red cells, we showed that the rate of lysis was dependent on the …

Amino acids present in blood plasma may be targets for oxidation and chlorination by
HOCl/OCl−. N-Chloroamino acids have been reported to be less reactive, but more selective …

Erythrocyte damage induced by hypochlorous acid (HOCl) results in cell lysis developing
with time after the oxidant is removed (post-hemolysis). The apparent rate constant of post …

Exposure of human red blood cells to low doses of hypochlorous acid (HOCl) resulted in the
loss of intracellular GSH. Oxidation occurred less than 2 min after the addition of HOCl, and …

The oxidation processes in normal and diabetic erythrocytes after cell exposure to H2O2
and t-butyl hydroperoxide, as well as the effect of malondialdehyde (a stable end product of …

The erythrocyte is a good model for investigation of the mechanisms of cell damage induced
by oxidizing agents. Oxidative damage to cell components and cellular metabolism results in …

Hypochlorous acid (HOCl), produced by activated neutrophils, is highly reactive oxidizing
and chlorinating agent of biologically relevant molecules. Hemoglobin (Hb), present in large …

The correlation between the oxidative processes in tert-butyl hydroperoxide (tBHP)-exposed
red blood cells and the reactions of oxygen consumption and release were investigated …