Endoplasmic reticulum stress inhibition enhances liver tolerance to ischemia/reperfusion

C Peralta, C Brenner - Current medicinal chemistry, 2011 - ingentaconnect.com
In many physiopathological conditions, the cell controls its proper dysfunction via activation
of the unfolded protein response to restore efficient protein synthesis and folding in the …

[HTML][HTML] Regulation mechanism of endoplasmic reticulum stress on metabolic enzymes in liver diseases

S Zhou, K Cheng, Y Peng, Y Liu, Q Hu, S Zeng… - Pharmacological …, 2024 - Elsevier
The endoplasmic reticulum (ER) plays a pivotal role in protein folding and secretion, Ca 2+
storage, and lipid synthesis in eukaryotic cells. When the burden of protein synthesis and …

Role of endoplasmic reticulum stress in hepatic glucose and lipid metabolism and therapeutic strategies for metabolic liver disease

W Zheng, Q Sun, L Li, Y Cheng, Y Chen, M Lv… - International …, 2022 - Elsevier
The endoplasmic reticulum is the most abundant membrane organelle in eukaryotic cells. It
is an important site of membrane and secretory protein folding and glycolipid synthesis and …

Endoplasmic reticulum stress-mediated cell death in liver injury

J Zhang, J Guo, N Yang, Y Huang, T Hu, C Rao - Cell death & disease, 2022 - nature.com
The endoplasmic reticulum is an important intracellular organelle that plays an important
role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded …

Relevance of endoplasmic reticulum stress cell signaling in liver cold ischemia reperfusion injury

E Folch-Puy, A Panisello, J Oliva, A Lopez… - International journal of …, 2016 - mdpi.com
The endoplasmic reticulum (ER) is involved in calcium homeostasis, protein folding and lipid
biosynthesis. Perturbations in its normal functions lead to a condition called endoplasmic …

Endoplasmic reticulum stress as a novel therapeutic target in heart diseases

A Toth, P Nickson, A Mandl… - … Current Drug Targets …, 2007 - ingentaconnect.com
The endoplasmic reticulum (ER) is a multifunctional organelle responsible for the synthesis
and folding of proteins as well as calcium storage and signaling. Perturbations of ER …

Cellular battle against endoplasmic reticulum stress and its adverse effect on health

S Divya, P Ravanan - Life Sciences, 2023 - Elsevier
The endoplasmic reticulum (ER) is a dynamic organelle and a reliable performer for
precisely folded proteins. To maintain its function and integrity, arrays of sensory and quality …

Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases

M Liu, Z Chen, L Chen - Acta Pharmacologica Sinica, 2016 - nature.com
Endoplasmic reticulum is a principal organelle responsible for folding, post-translational
modifications and transport of secretory, luminal and membrane proteins, thus palys an …

Pharmacological modulators of endoplasmic reticulum stress in metabolic diseases

TW Jung, KM Choi - International journal of molecular sciences, 2016 - mdpi.com
The endoplasmic reticulum (ER) is the principal organelle responsible for correct protein
folding, a step in protein synthesis that is critical for the functional conformation of proteins …

Hepatic topographical changes of endoplasmic reticulum stress and unfolded protein response signaling after hemorrhagic shock and reperfusion

A Wolpert, D Obert, B Frey, YS Lee, S Korff - Journal of Surgical Research, 2018 - Elsevier
Background Endoplasmic reticulum (ER) stress plays a crucial role in cell death decisions in
context of various diseases. Although it is known that ER stress occurs in livers subjected to …