Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity

JP Renn, JYA Doritchamou, BCN Tentokam… - Communications …, 2021 - nature.com
Plasmodium falciparum-infected erythrocytes (IE) sequester in the placenta via surface
protein VAR2CSA, which binds chondroitin sulfate A (CSA) expressed on the …

[HTML][HTML] Designing a VAR2CSA-based vaccine to prevent placental malaria

M Fried, PE Duffy - Vaccine, 2015 - Elsevier
Placental malaria (PM) due to Plasmodium falciparum is a major cause of maternal, fetal
and infant mortality, but the mechanisms of pathogenesis and protective immunity are …

Can any lessons be learned from the ambiguous glycan binding of PfEMP1 domains?

M Dahlbäck, MA Nielsen, A Salanti - Trends in parasitology, 2010 - cell.com
Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected
erythrocytes (IEs) accumulating in the placenta and has dire consequences for both mother …

Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA

M Avril, BR Kulasekara, SO Gose, C Rowe… - Infection and …, 2008 - Am Soc Microbiol
Pregnancy-associated malaria (PAM) is characterized by the placental sequestration of
Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin …

A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?

JYA Doritchamou, JP Renn, L Hviid, PE Duffy - PLoS Pathogens, 2023 - journals.plos.org
VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …

Towards a vaccine against pregnancy-associated malaria

NT Ndam, P Deloron - Parasite, 2008 - parasite-journal.org
The consequences of pregnancy-associated malaria on pregnant women (anaemia), their
babies (birth weight reduction), and infants (increased morbidity and mortality) are well …

Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites

P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …

A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates

JYA Doritchamou, JP Renn, B Jenkins, A Mahamar… - Elife, 2022 - elifesciences.org
Placental malaria (PM) is a deadly syndrome most frequent and severe in first pregnancies.
PM results from accumulation of Plasmodium falciparum-infected erythrocytes (IE) that …

Identification of Plasmodium falciparum var1CSA and var2CSA domains that bind IgM natural antibodies

JP Semblat, A Raza, SA Kyes, JA Rowe - Molecular and biochemical …, 2006 - Elsevier
Malaria in pregnancy is responsible for maternal anaemia, low-birth-weight babies and
infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental …

Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes

M Avril, MM Cartwright, MJ Hathaway… - Infection and …, 2010 - Am Soc Microbiol
Pregnancy-associated malaria is a severe clinical syndrome associated with the
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …