Importance Nitric oxide precursors, such as the amino acidl-arginine and the biguanide
antidiabetic drug metformin, have been associated with metabolism and muscle function in …

Background Duchenne muscular dystrophy (DMD) is an X-linked recessive disease that
affects 1 in 3500–6000 male births. Despite broad research aiming to improve muscle …

While the number of new treatment options tested in patients with Duchenne muscular
dystrophy (DMD) is increasing, there is still no defining of the most reliable assessments …

Altered neuronal nitric oxide synthase function in Duchenne muscular dystrophy leads to
impaired mitochondrial function which is thought to be one cause of muscle damage in this …

Importance Corticosteroidal anti-inflammatory drugs are widely prescribed but long-term use
shows adverse effects that detract from patient quality of life. Objective To determine if …

Importance Corticosteroids improve strength and function in boys with Duchenne muscular
dystrophy. However, there is uncertainty regarding the optimum regimen and dosage …

Introduction In this study we characterized disease progression over 48 weeks among boys
receiving deflazacort vs prednisone/prednisolone placebo arm treatment in two recent …

Outcome measures in Duchenne muscular dystrophy: sensitivity to change, clinical
meaningfulness, and implications for clinical trials. - Abstract - Europe PMC Sign in | Create an …

Background: In the absence of a curative treatment for Duchenne Muscular Dystrophy
(DMD), corticosteroid therapy (prednisone, deflazacort) has been adopted as the standard of …

Background Prednisone treatment is used to prolong ambulation in patients with Duchenne
muscular dystrophy (DMD). However, since severe adverse effects often accompany …