In this study, IC50 shift and time-dependent inhibition (TDI) experiments were carried out to
measure the ability of amiodarone (AMIO), and its circulating human metabolites, to …

Aims To predict the drug interactions of amiodarone and other drugs, the inhibitory effects
and inactivation potential for human cytochrome P450 (CYP) enzymes by amiodarone and …

Amiodarone (AMI) is a potent antiarrhythmic drug, but its metabolism has not yet been fully
documented. Mono-N-desethylamiodarone (MDEA) is its only known metabolite. Our …

In humans, cytochrome P450 3A (CYP3A4) is a major enzyme involved in the metabolism of
amiodarone (AM) to its major metabolite, desethylamiodarone (DEA). In rat, a commonly …

PURPOSE. To evaluate the metabolism of amiodarone (AM) to desethylamiodarone (DEA)
by selected human and rat cytochrome P450, and the inhibitory effect of ketoconazole (KTZ) …

Human cytochrome P450 (CYP) isoforms involved in amiodarone N-deethylation were
identified, and the relative contributions of these CYP isoforms were evaluated in different …

In mammals, mono-N-desethylamiodarone (MDEA) is the only known metabolite of
amiodarone. Our previous experiments demonstrated that in vitro MDEA may be …

Amiodarone is a class III antiarrhythmic drug with potentially life-threatening hepatotoxicity.
Recent in vitro investigations suggested that the mono-N-desethyl (MDEA) and di-N …

Amiodarone is recognized as an effective drug in the treatment of arrhythmias. Previous
experiments demonstrated that mono-N-desethylamiodarone (MDEA) was the major …

1. Amiodarone (AMI) is a potent anti-arrhythmic drug and mono-N-desethylamiodarone
(MDEA) is its only known metabolite. It was found recently that in rabbit liver microsomes …