Depressive disorders are complex, multifactorial mental disorders with unknown
neurobiology. Numerous theories aim to explain the pathophysiology. According to the …

Several structural and cellular changes, including marked glial anomalies, have been
observed in association with major depressive disorder. Here we review these cellular …

Major depressive disorder (MDD) is a mood disorder of multifactorial origin affecting millions
of people worldwide. The alarming estimated rates of prevalence and relapse make it a …

Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …

Recent studies combining pharmacological, behavioral, electrophysiological and molecular
approaches indicate that depression results from maladaptive neuroplastic processes …

Significant stress exposure and psychiatric depression are associated with morphological,
biochemical, and physiological disturbances of astrocytes in specific brain regions relevant …

Neurons have been considered the major functional entities of the nervous system that are
responsible for most of the functions even though glial cells largely outnumber them …

Recent research has changed the perception of glia from being no more than silent
supportive cells of neurons to being dynamic partners participating in brain metabolism and …

Despite intense ongoing research efforts, the etiology of psychiatric disorders remains
incompletely understood. Among biological factors playing a role in Major Depressive …

In psychiatric diseases such as mood disorders or schizophrenia, the inflammatory response
system is activated. Microglia has gradually emerged as a key interface between stress …