Chronic pain afflicts millions of people, commonly causing depression and anxiety. These
conditions must be treated to achieve a good functional outcome from pain treatment …

Depression and painful somatic symptoms commonly occur together. Depression and
chronic pain can have devastating effects on a patient's health, productivity, and overall …

Chronic pain is considered one of the most prevalent causes of costly and disabling medical
conditions. This review will define chronic pain and its categories and then will summarize …

Background: Emotional disorders are common comorbid affectations that exacerbate the
severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an …

Antidepressants exhibit a number of pharmacological mechanisms, including
norepinephrine and serotonin modulation, direct and indirect effects on opioid receptors …

Chronic pain is both difficult for patients to tolerate and for clinicians to treat effectively. It
differs from other types of pain in etiology and impact, which in turn affects the duration and …

Antidepressant drugs have been used successfully in the treatment of chronic pain
syndromes. Clinical trials have supported the use of these drugs for pain and the depression …

Healing or successful intervention usually leads to the resolution of pain. However, in some
patients biologic or psychologic symptoms associated with pain persist despite treatment or …

Some antidepressants may be efficacious in alleviating pain. While few studies have directly
compared antidepressants for the treatment of painful physical symptoms, meta-analyses of …

Antidepressant drugs have gained widespread clinical usage alone or as adjuncts in the
treatment of chronic pain disorders. Of 17 controlled studies of antidepressants in chronic …