Abstract 53BP1 mediates DNA repair process in somatic cells; however, the function of
53BP1 in germline stem cells still remains unclear. In the present study, animals and cells …

The present study aims to examine the effect of low-dose ionizing irradiation on DNA double
strand breaks (DSB) in mouse spermatogonial stem cells (SSCs) and reveal the underlying …

DNA double-strand break (DSB) repair is crucial to maintain genomic stability for sufficient
ovarian reserve. It remains unknown the changes of DSBs formation and DNA repair in germ …

Spermatogenesis is a complex developmental process. During this process, male germ cells
from spermatogonia to sperm cells encounter a number of DNA damages. The most severe …

The present study was designed to detect DNA repair response through the homologous
recombination pathway in mouse spermatogonial stem cells. Mouse spermatogonial stem …

Spermatogonial stem cells (SSCs) undergo self-renewal divisions to provide the foundation
for spermatogenesis. Although Rb1 deficiency is reportedly essential for SSC self-renewal …

Compelling evidence suggest that germs cells are predominantly sensitive to DNA
damaging agents in comparison to other cells. High fidelity DNA repair in testicular cells thus …

Germ cells are thought to exhibit a unique DNA damage response that differs from that of
somatic stem cells, and previous studies suggested that Trp53 is not involved in the survival …

DNA repair processes are critical to maintaining genomic integrity. As a result, dysregulation
of repair genes is likely to be linked with health implications, such as an increased …

Bisphenol A (BPA) is widely used as an industrial plasticizer, which is also an endocrine
disruptor and considered to have adverse effects on reproduction. In male mammals, the …