C57BL/6J mice were fed a high-fat, carbohydrate-free diet (HFD) for 9 mo. Approximately
50% of the mice became obese and diabetic (ObD),∼ 10% lean and diabetic (LD),∼ 10 …

We investigated the effects of diet-induced obesity on glucose metabolism in two strains of
mice, C57BL/6J and A/J. Twenty animals from each strain received ad libitum exposure to a …

We have previously shown that C57BL/6J (B6) mice develop severe obesity and diabetes if
weaned onto high-fat diets, whereas A/J mice tend to be obesity and diabetes-resistant. The …

Objective: The aim of this study was to assess the suitability of A/J and C57BL/6J mice of
both sexes as models of some components of the human metabolic syndrome (MetS) under …

C57BL/6J (B6) and AKR/J (AKR) inbred strains of mice develop a comparable degree of
obesity when fed a high-fat diet. However, although obese B6 mice are more glucose …

We hypothesized that variation in dietary fatty acid composition in rats fed a high-fat diet had
tissue-specific effects on glucose uptake sufficient to maintain normal glucose tolerance …

This study characterizes the high-fat diet–fed mouse as a model for impaired glucose
tolerance (IGT) and type 2 diabetes. Female C57BL/6J mice were fed a high-fat diet (58 …

Aims/hypothesis Metabolic disorders are commonly investigated using knockout and
transgenic mouse models. A variety of mouse strains have been used for this purpose …

We have previously demonstrated that the C57BL/6J (B 6J) mouse will develop severe
obesity, hyperglycemia, and hyperinsulinemia if weaned onto a high-fat, high-sucrose (HH) …

Male Zucker diabetic fatty fa/fa (ZDF) rats develop obesity and insulin resistance at a young
age, and then with aging, progressively develop hyperglycemia. This hyperglycemia is …