Previous in vivo and in vitro studies have shown that Akt1 serves as a crucial regulator of
vascular maturation, extracellular matrix composition, and angiogenesis in tumors. Hence …

Akt, a serine-threonine kinase, regulates multiple cellular processes in vascular cells. We
have previously documented that Akt activates integrins and Akt1 deficiency results in matrix …

Akt signaling is involved in tumorigenesis via a number of different mechanisms that result in
increased proliferation and decreased apoptosis. Previous data have demonstrated that Akt …

Here we investigated the potential role of protein kinase B (Akt) in normal or diabetes-
impaired wound healing in mice. Interestingly, Akt1 was predominant in skin, wound tissue …

VEGF and Angiopoietin (Ang) 1 are growth factors that independently improve wound
healing outcomes. Using a tet-repressible mouse model coupled with streptozotocin …

Akt1 belongs to the three‐gene Akt family and functions as a serine–threonine kinase
regulating phosphorylation of an array of substrates and mediating cellular processes such …

Akt, or protein kinase B, is a multifunctional serine-threonine protein kinase implicated in a
diverse range of cellular functions including cell metabolism, survival, migration, and gene …

Postnatal neovascularization has been known to be involved in not only angiogenesis but
also vasculogenesis. Several lines of evidence suggest a link between neovascularization …

Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …

The mouse skin carcinogenesis protocol is a unique model for understanding the molecular
events leading to oncogenic transformation. Mutations in the Ha-ras gene, and the presence …