Background Vascular malformations are clinical disorders in which endothelial cells fail to
remodel and/or undergo programmed cell death, leading to abnormal persistence of blood …

To determine how AKT2 might contribute to tumor cell progression, a full-length, wild-type,
human AKT2/protein kinase B (PKB) β cDNA was transfected into a panel of eight human …

Objective—The importance of PI3K/Akt signaling in the vasculature has been demonstrated
in several models, as global loss of Akt1 results in impaired postnatal ischemia-and VEGF …

Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as
migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the …

Normal tissue function requires adequate supply of oxygen through blood vessels.
Understanding how blood vessels form is a challenging objective because angiogenesis is …

AKT signaling and M2 macrophage-guided tissue repair are key factors in cutaneous wound
healing. A delay in this process threatens human health worldwide. However, the role of …

AKT is a central signaling molecule in regulating cell survival, proliferation, tumor growth
and angiogenesis. Upstream components of AKT signaling pathway such as PI3K, PTEN …

Tie2 and VEGF receptors (VEGFRs) are tyrosine kinases that play essential roles in
angiogenesis. Activation of both receptors leads to the activation of Akt, an important …

Akt is a serine/threonine protein kinase that is activated by a number of growth factors and
cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic …

Akt-mediated signaling plays an important role in blood vascular development. In this study,
we investigated the role of Akt in lymphatic growth using Akt-deficient mice. First, we found …