Akt-mediated signaling plays an important role in blood vascular development. In this study,
we investigated the role of Akt in lymphatic growth using Akt-deficient mice. First, we found …

Although numerous factors are implicated in skin fibrosis, the exact pathophysiology of
hypertrophic scarring remains unknown. We recently demonstrated that mechanical force …

The PI3K/Akt pathway is necessary for several key endothelial cell (EC) functions, including
cell growth, migration, survival, and vascular tone. However, existing literature supports the …

It has become evident that a closely regulated presence of vascular endothelial growth
factor (VEGF) and angiopoietin (Ang) factors determines the fate of blood vessel formation …

In adult skin wounds, collagen expression rapidly re-establishes the skin barrier, although
the resultant scar is aesthetically and functionally inferior to unwounded tissue. Although …

Background: Formation of new blood vessels, by either angiogenesis or vasculogenesis, is
critical for normal wound healing. Major processes in neovascularization include (i) growth …

Akt1 is implicated in cell metabolism, survival migration, and gene expression; however, little
is known about the role of specific Akt isoforms during inflammation in vivo. Thus, we directly …

The Akt family of kinases are activated by growth factors and regulate pleiotropic cellular
activities. In this study, we provide evidence for isoform-specific positive and negative roles …

During cutaneous wound healing, keratinocyte proliferation and migration are critical for re-
epithelialization. In addition the epidermis secretes growth factors, cytokines, proteases, and …

The tissue angiotensin (Ang) system, which acts independently of the circulating renin Ang
system, is supposed to play an important role in tissue repair in the heart and kidney. In the …