Background Wound healing is impaired in diabetes mellitus. The underlying mechanism
involved in this process is still unknown. The Akt/mTOR signaling pathway plays a crucial …

The cutaneous lymphatic system plays a major role in tissue fluid homeostasis and
inflammation of the skin. Although several lymphangiogenic factors are known to be …

Development of wound therapies is hindered by poor understanding of combinatorial
integrin function in the epidermis. In this study, we generated mice with epidermis-specific …

Epithelial-mesenchymal transition (EMT) is an important process during development and
oncogenesis by which epithelial cells acquire fibroblast-like properties and show reduced …

Background Activin B has been reported to promote the proliferation and migration of
keratinocytes in vitro via the RhoA-JNK signaling pathway, whereas its in vivo role and …

Poor wound healing and pathological healing have been pressing issues in recent years, as
they impact human quality of life and pose risks of long-term complications. The study of …

Proliferation and migration of epidermal keratinocytes are essential for proper cutaneous
wound closure after injury. αv integrins and several of their ligands—vitronectin, TGFβ and …

Fibroblasts are the main cells of connective tissue and have pivotal roles in the proliferative
and maturation phases of wound healing. These cells can secrete various cytokines, growth …

Integrins are ubiquitous transmembrane receptors that play crucial roles in cell-cell and cell-
matrix interactions. In this study, we have determined the effects of the loss of β1 integrins in …

Significance: Abnormal wound repair results from disorders in granulation tissue
remodeling, and can lead to hypertrophic scarring and fibrosis. Excessive scarring can …