Acutely transforming retrovirus AKT8 in rodent T-cell lymphoma (Akt) is a serine/threonine
kinase that plays important roles in survival, cell-cycle progression, and cell proliferation …

Wound healing is a multistage process involving collaborative efforts of different cell types
and distinct cellular functions. Among others, the high metabolic activity at the wound site …

After cutaneous injury, keratinocytes secrete paracrine factors that regulate wound cell
functions; dysregulation of this signaling can lead to wound pathologies. Previously, we …

The serine/threonine protein kinase Akt is a major transducer of the phosphoinositide 3-
kinase pathway and plays a crucial role in regulation of cellular processes such as growth …

Previous wound healing studies have failed to define a role for either α1β1 or α2β1 integrin
in fibroblast-mediated wound contraction, suggesting the involvement of another collagen …

VEGF is an endothelial cell cytokine that promotes angiogenesis and enhances
microvascular permeability. Recently, it has been shown that the protein kinase Akt functions …

The treatment of festering wounds is one of the most important aspects of medical care.
Macrophages are important components of wound repair, both in fending off infection and in …

Decades of research have elucidated the critical role of Akt isoforms in cancer as pro-
tumorigenic and metastatic regulators through their specific effects on the cancer cells, tumor …

The Akt/PKB serine/threonine protein kinase consists of three isoforms: Akt-1,− 2 and− 3.
Their overexpression has been detected in human cancers, but their roles in cancer …

A key central stage of wound healing requires neovascularization of the wound base
granulation tissue. In the adult, neovascularization is now known to occur by both …