The following analysis will be based on several major assumptions: namely, carcinogenesis,
in the main, can be conceptualized by the initiationipromotion concept (1-4); and the …

James E. Trosko, Chia-Cheng Chang, Burra V. Madhukar, and Emmanuel Dupont... during
the critical periods, the cancer cells are susceptible to the influence of the host and are …

Empirical observations of tumorigenesis in animal and human systems clearly indicate that it
is a multistep process.'After the stable conversion of a single normal cell to a “premalignant” …

Three major theories of cancer--somatic mutation, virus causation, and faulty differentiation--
are proposed to involve alterations in DNA structure. Each results finally in terms of failures …

Current research on the mode of action of tumor promoters is largely based on the following
premises:(a) that the initiating phase of the multi-stage process of carcinogenesis is brought …

In order to ascertain whether there might be a scientific basis for determining practical
“thresholds” for “carcinogens,” the concepts of thresholds and carcinogens were examined …

Although this analytical review is presented as part of a symposium on radiation
carcinogenesis, its scope has been extended to include carcinogens other than radiation …

There are more things in heaven and earth, Horatio, of Weinberg et al, which demonstrated
that DNA of Than are dreamt of in your philosophy. mouse cells transformed by 3-methyl …

The precise mechanism (s) whereby normal cells become malignant are not known with any
degree of certainty. However, many mechanisms have been proposed on the basis of …

Multiple factors contribute to the development of neoplasia. Sometimes a single agency can
bring about a tumour if it has many different effects, but at other times a tumour arises more …