Diagnosis of Parkinson's disease (PD) is based on the presentation of clinical symptoms
such as bradykinesia, resting tremor, and rigidity. However, one feature of PD that often …

Dietary restriction (DR) extends life span and improves glucose metabolism in mammals.
Recent studies have shown that DR stimulates the production of brain-derived neurotrophic …

Partial symptomatic relief from Parkinson's disease with levodopa has proven to be one of
the rare success stories in the development of drugs to combat neurodegenerative diseases …

We previously reported that brain-derived neurotrophic factor (BDNF) regulates both food
intake and blood glucose metabolism in rodent obese diabetic models such as C57BL/KsJ …

The primate striatum contains tyrosine hydroxylase (TH)-immunoreactive (ir) neurons, the
numbers of which are augmented after dopamine depletion. Glial cell line-derived …

Abstract Effects of a single injection of either 150 μg human recombinant glial cell line‐
derived neurotrophic factor (rGDNF) or vehicle into the right substantia nigra were analyzed …

Food restriction (FR) in rodents is known to extend life span, reduce the incidence of age‐
related tumors, and suppress oxidative damage to proteins, lipids, and DNA in several organ …

Glial cell line-derived neurotrophic factor (GDNF) has been shown to increase dopaminergic
parameters in vitro and in vivo and can reduce parkinsonian behaviors in animal models of …

Injection of an adenoviral (Ad) vector encoding human glial cell line-derived neurotrophic
factor (GDNF) protects dopaminergic (DA) neurons in the substantia nigra (SN) of young …

Glial cell line‐derived neurotrophic factor (GDNF) improves motor dysfunction associated
with aging in rats and non‐human primates, in animal models of Parkinson's disease, and …