Brain-derived neurotrophic factor (BDNF) has been shown to promote the survival of
dopaminergic neurons from the substantia nigra in cell culture. In order to assess whether a …

The therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) for Parkinson's
disease is likely to depend on sustained delivery of the appropriate amount to the target …

Although all cells in the body require energy to survive and function properly, excessive
calorie intake over long time periods can compromise cell function and promote disorders …

Clinical studies have indicated a link between Parkinson's disease (PD) and Type 2
Diabetes. Although preclinical studies have examined the effect of high-fat feeding on …

A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was
purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated …

Recently, a novel glial cell line-derived neurotrophic factor (GDNF) has been identified,
cloned, and shown to have potent survival-and growth-promoting activity on fetal rat …

Transgenic mice overexpressing brain-derived neurotrophic factor from the β-actin promoter
were tested for behavioral, gross anatomical and physiological abnormalities. Brain-derived …

Mice unable to synthesize dopamine (DA) specifically in dopaminergic neurons were
created by inactivating the tyrosine hydroxylase (TH) gene then by restoring TH function in …

While we recently reported the beneficial effects of omega-3 polyunsaturated fatty acids (n−
3 PUFAs) in a mouse model of Parkinson's disease (PD), the mechanisms of action remain …

There is evidence that central infusion of brain-derived neurotrophic factor (BDNF) induces
weight loss in rats. We have begun to investigate the physiological basis for BDNF-induced …