Valproic acid (VPA) is a blocker of histone deacetylase widely used to treat epilepsy, bipolar
disorders, and migraine; its administration during pregnancy increases the risk of autism …

We aimed to investigate the effect of prenatal administration of valproic acid (VPA)(500
mg/kg) at embryonic day 12.5 on the anatomical properties of the prefrontal cortex …

Autism Spectrum Disorder (ASD) is one of the most frequently diagnosed
neurodevelopmental disorders, characterized among others by impairments in social …

Autism spectrum disorders (ASD) are neurodevelopmental disorders, that are characterized
by core symptoms, such as alterations of social communication and restrictive or repetitive …

Autism is a highly debilitating disorder that has recently displayed a dramatic rise in
incidence. In order to realistically study preventative and remedial strategies, it is important …

Simple Summary Valproic acid (VPA) is a well-known antiepileptic medication and mood
stabiliser that is frequently prescribed for the treatment of epilepsy, particularly in children …

Autism spectrum disorder (ASD) has a broad range of neurobiological characteristics,
including alterations in dendritic spines, where approximately 90% of excitatory synapses …

Maternal use of valproic acid (VPA) during pregnancy has been implicated in the aetiology
of autism spectrum disorders in children, and rodents prenatally exposed to VPA showed …

Autism is a severe behavioral disorder characterized by pervasive impairments in social
interactions, deficits in verbal and nonverbal communication, and stereotyped, repetitive …

Prenatal exposure to the antiepileptic and mood stabilizer valproic acid (VPA) is an
environmental risk factor for autism spectrum disorders (ASD), although recent …