Purpose: Investigations on the combination of radiotherapy with vascular endothelial growth
factor (VEGF) and platelet-derived growth factor (PDGF) antiangiogenic agents, which has …

In recent decades, radiation research has concentrated primarily on the cancer cell
compartment. Much less is known about the effect of ionizing radiation on the endothelial …

The formation of new blood vessels (angiogenesis) represents a critical factor in the
malignant growth of solid tumors and metastases. Vascular endothelial cell growth factor …

Background Several small receptor tyrosine kinase inhibitors (RTKI) have entered clinical
cancer trials alone and in combination with radiotherapy or chemotherapy. The inhibitory …

The vascular endothelial growth factor (VEGF) receptor is a major target for anti-
angiogenesis-based cancer treatment. Here we report the treatment effect of ionizing …

Purpose In this study, the efficacy of combining ZD6474 (Zactima), a vascular endothelial
growth factor (VEGF) receptor 2–associated tyrosine kinase inhibitor currently undergoing …

PURPOSE: This is the first preclinical report evaluating a trimodal therapy consisting of
irradiation, chemotherapy, and antiangiogenesis in the context of a multimodal anticancer …

PURPOSE: Previous experiments have shown that adjuvant inhibition of the vascular
endothelial growth factor receptor after fractionated irradiation prolonged tumor growth delay …

Previous experiments with PTK787/ZK222584, a specific inhibitor of vascular endothelial
growth factor receptor (VEGFR) tyrosine kinases, using irradiated human FaDu squamous …

The effects of antiangiogenic therapy on tumors relapsing after irradiation are not known. To
this end, we irradiated human tumors growing sc in nude mice with a single dose of 20 or 30 …