KLK4 induces anti-tumor effects in human xenograft mouse models of orthotopic and metastatic prostate cancer

BWC Tse, T Kryza, MC Yeh, Y Dong, KA Sokolowski… - Cancers, 2020 - mdpi.com
Simple Summary The serine protease kallikrein-related peptidase 4 (KLK4) has been
reported to potentially play a role in the progression of prostate cancer and other cancer …

The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer

T Kryza, N Bock, S Lovell, A Rockstroh… - Molecular …, 2020 - Wiley Online Library
Kallikrein‐related peptidase 14 (KLK14) is one of the several secreted KLK serine proteases
involved in prostate cancer (PCa) pathogenesis. While relatively understudied, recent …

Polyclonal antibodies against kallikrein-related peptidase 4 (KLK4): immunohistochemical assessment of KLK4 expression in healthy tissues and prostate cancer

L Seiz, M Kotzsch, NI Grebenchtchikov… - 2010 - degruyter.com
KLK4 is a member of the human kallikrein-related peptidase family of (chymo) trypsin-like
serine proteases. The aim of the present study was to generate polyclonal antibodies (pAb) …

Biochemical characterization of human tissue kallikrein 15 and examination of its potential role in cancer

PS Filippou, AH Ren, S Bala, MD Papaioannou… - Clinical …, 2018 - Elsevier
Objective Human tissue kallikrein 15 (KLK15) is the last cloned member of the KLK-related
gene family. Despite being implicated in multiple cancers, its pathophysiological role …

Compartmentalized expression of kallikrein 4 (KLK4/hK4) isoforms in prostate cancer: nuclear, cytoplasmic and secreted forms

Y Dong, LT Bui, DM Odorico, OL Tan… - Endocrine-related …, 2005 - erc.bioscientifica.com
The prostate-specific antigen-related serine protease gene, kallikrein 4 (KLK4), is expressed
in the prostate and, more importantly, overexpressed in prostate cancer. Several KLK4 …

Human kallikrein‐related peptidase 12: Antibody generation and immunohistochemical localization in prostatic tissues

N Memari, EP Diamandis, T Earle, A Campbell… - The …, 2007 - Wiley Online Library
Background Human tissue kallikrein‐related peptidases (genes, KLKs; proteins, KLKs) are a
subgroup of serine proteases present in a variety of tissues and biological fluids. A number …

Biochemical pathways mediated by KLK 6 protease in breast cancer

G Pampalakis, E Zingkou, KG Sidiropoulos… - Molecular …, 2019 - Wiley Online Library
Kallikrein‐related peptidase 6 (KLK 6) is a serine protease normally expressed in mammary
tissue and aberrantly regulated in breast cancer. At physiological levels, KLK 6 functions as …

Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer

F Walker, P Nicole, A Jallane, A Soosaipillai… - Biological …, 2014 - degruyter.com
Emerging evidence indicates that serine proteases of the tissue kallikrein-related peptidases
family (KLK) are implicated in tumorigenesis. We recently reported the ectopic expression of …

The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6)

J Bayani, EP Diamandis - Clinical chemistry and laboratory medicine, 2012 - degruyter.com
The human kallikrein-related peptidase 6 (KLK6) gene belongs to the 15-member kallikrein
(KLK) gene family mapping to chromosome 19q13. 3–13.4. Encoding for an enzyme with …

KLK5 gene expression is severely upregulated in androgen-independent prostate cancer cells after treatment with the chemotherapeutic agents docetaxel and …

K Mavridis, M Talieri, A Scorilas - 2010 - degruyter.com
Abstract Kallikrein-related peptidases (KLKs), including KLK5, have been proposed as
promising biomarkers for prostate cancer diagnosis and prognosis. In the present study, we …