The kidney is widely regarded as an organ without regenerative abilities. However, in recent
years this dogma has been challenged on the basis of observations of kidney recovery …

Fifteen years ago, this journal published a review outlining future options for regenerating
the kidney. At that time, stem cell populations were being identified in multiple tissues, the …

In most adult epithelia the process of replacing damaged or dead cells is maintained
through the presence of stem/progenitor cells, which allow epithelial tissues to be repaired …

Kidney disease is an escalating burden all over the world. In addition to preventing kidney
injury, regenerating damaged renal tissue is as important as to retard the progression of …

A kidney is an organ with relatively low basal cellular regenerative potential. However, renal
cells have a pronounced ability to proliferate after injury, which undermines that the kidney …

Direct reprogramming involves the enforced re-expression of key transcription factors to
redefine a cellular state. The nephron progenitor population of the embryonic kidney gives …

Previous studies have suggested that CD133+ cells isolated from human kidney biopsies
have the potential to ameliorate injury following intravenous (IV) administration in rodent …

Adult stem cells have been characterized in several tissues as a subpopulation of cells able
to maintain, generate, and replace terminally differentiated cells in response to physiological …

The mammalian kidney is a highly complex organ that requires the precise structural
arrangement of multiple cell types for effective function. The need to filter large volumes of …

Stem cells in the kidney. The kidney is derived from the ureteric bud and the
metanephrogenic mesenchyme, and these two progenitor cells differentiate into more than …