A current explanation for development of chronic renal injury is the imbalance between
injurious mechanism and regenerative repair. The possibility that stem cells contribute to the …

Transplantation of murine bone marrow-derived stem cells has been reported recently to
promote regeneration of the injured kidney. We investigated the potential of human adult …

Chronic kidney disease (CKD) is a global health problem; the growing gap between the
number of patients awaiting transplant and organs actually transplanted highlights the need …

Renal cells are used in basic research, disease models, tissue engineering, drug screening,
and in vitro toxicology. In order to provide a reliable source of human renal cells, we …

Acute tubular necrosis is followed by regeneration of damaged renal tubular epithelial cells,
and renal stem cells are supposed to contribute to this process. The purpose of our study is …

Although many of the molecular interactions in kidney development are now well
understood, the molecules involved in the specification of the metanephric mesenchyme …

For chronic kidney diseases, there is little chance that the vast majority of world's population
will have access to renal replacement therapy with dialysis or transplantation. Tissue …

The prevalence of renal diseases is emerging as a public health problem. Despite major
progress in supportive therapy, mortality rates among patients remain high. In an attempt to …

Significant progress has been made to advance stem cell products as potential therapies for
kidney diseases: various kinds of stem cells can restore renal function in preclinical models …

Glomerular injury and podocyte loss leads to secondary tubulointerstitial damage and the
development of fibrosis. The possibility of genetically reprogramming adult cells, termed …