The kidney has a dramatic capacity to regenerate after injury. Whether stem cells are the
source of the epithelial progenitors replacing injured and dying tubular epithelium is …

Recent advancement in developmental biology has led to the discovery of immature
mesenchymal stem cells in bone marrow and several established organs. The therapeutic …

Transit-amplifying nephron progenitor cells (NPCs) generate all of the nephrons of the
mammalian kidney during development. Their limited numbers, poor in vitro expansion, and …

A rising number of patients with acute and chronic renal failure worldwide have created
urgency for clinicians and investigators to search out alternative therapies other than chronic …

Every year 13.3 million people suffer acute kidney injury (AKI), which is associated with a
high risk of death or development of long-term chronic kidney disease (CKD) in a substantial …

Within the developing mammalian kidney, several populations of progenitors form the
discrete cellular components of the final organ. Fate mapping experiments revealed the cap …

Ischemia-reperfusion injury (I/R injury) is a common cause of acute renal failure. Recovery
from I/R injury requires renal tubular regeneration. Hematopoietic stem cells (HSC) have …

Animal fetuses and embryos may have applications in the generation of human organs.
Progenitor cells may be an appropriate cell source for regenerative organs because of their …

For nearly 100 years, developmental biologists have utilized fate mapping to understand the
contributions of progenitor populations to organogenesis. More recently, Cre-Lox technology …

In the past few years, adult renal progenitor/stem cells (ARPCs) have been identified in
human kidneys, and particularly in Bowman's capsule and proximal tubules. They may play …